Prof. Dr. Nazlı Başak
ALS, a non-curable brain disease, is characterized by rapid neurodegeneration of motor neurons in the brain and brainstem, resulting in progressive weakness and death within a few years of onset. The etiology of ALS remains unknown despite intensive research. Recent landmark papers have demonstrated a role for specific gut microorganisms and their metabolites in the development of ALS. 

Prof. A. Nazlı Başak from The School of Medicine (KUTTAM-NDAL, Suna and İnan Kıraç Foundation) and Asst. Prof. Hamza Syed from KUTTAM will reveal the role of these microorganisms and their metabolites, which are thought to play a role in the development of ALS, as potential biomarkers and modifiable treatment targets in the dysbiotic microbiome (the complement of microorganisms in the gastrointestinal tract). The aim of the project is to establish a multinational collaboration to better understand the interaction of the microbiome and its relationship to ALS.